Single amino acid insertions in extracellular loop 2 of Bombyx mori ABCC2 disrupt its receptor function for Bacillus thuringiensis Cry1Ab and Cry1Ac but not Cry1Aa toxins
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- 作者：Shiho Tanakaa ; Kazuhisa Miyamotob ; Hiroaki Nodab ; Haruka Endoa ; Shingo Kikutaa ; Ryoichi Satoa ; ryoichi@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bt ; Bacillus thuringiensis ; ABCC2 ; ABC transporter C2 ; BtR175 ; cadherin-like receptor in Bombyx mori ; BBMV ; brush border membrane vesicles
- 刊名：Peptides
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：99-108
- 全文大小：3453 K
文摘
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It is likely that extracellular loop 2 region of BmABCC2_S is not a binding site for Cry1A toxins but work as a specificity determinant.
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Any amino acid insertions in loop 2 of BmABCC2 at position 234 could result in a loss of receptor function.
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Domain II of Cry1A toxin is relevant to modification of host specificity against BmABCC2_R(+234Y)-expressing cells.