Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats
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- 作者：Ayako Shirakia ; b ; shirakia@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takeshi Tanakaa ; b ; tatanaka@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yousuke Watanabea ; b ; ywatana@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Fumiyo Saitoc ; saito-fumiyo@ceri.jp" class="auth_mail" title="E-mail the corresponding author ; Yumi Akahoric ; akahori-yumi@ceri.jp" class="auth_mail" title="E-mail the corresponding author ; Nobuya Imatanakac ; imatanaka-nobuya@ceri.jp" class="auth_mail" title="E-mail the corresponding author ; Toshinori Yoshidaa ; yoshida7@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Makoto Shibutania ; mshibuta@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARC ; activity-regulated cytoskeleton-associated protein ; CA ; cornu ammonis ; CALB2 ; calbindin-D-29K ; COX2 ; cyclooxygenase-2 ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; DCX ; doublecortin ; DNT ; developmental neurotoxicity ; DPYSL3 ; dihydropyrimidinase-like 3 ; EOMES ; eomesodermin ; EPHA4 ; Eph receptor A4 ; FOS ; FBJ osteosarcoma oncogene ; GABA ; γ-aminobutyric acid ; GCL ; granule cell layer ; GD ; gestational day ; GFAP ; glial fibrillary acidic protein ; NPY ; neuropeptide Y ; PVALB ; parvalbumin ; PAX6 ; paired box 6 ; PCN
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：2 November 2016
- 年：2016
- 卷：261
- 期：Complete
- 页码：59-71
- 全文大小：6540 K
文摘
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DNT parameters were examined in rat PTU-induced hypothyroidism models.
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DNT parameters were also examined in an adult-onset hypothyroidism model.
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Interneuron changes may be indicative of DNT parameters during development.
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Synaptic plasticity and hippocampal neurogenesis are sensitive to PTU-induced DNT.
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Hippocampal neurogenesis is sensitive to adult-stage PTU exposure.