Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis

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• 作者：Marcele Araú ; jo Silva Mantoan ; Luí ; s Otá ; vio Sales Ferreira Caboclo ; Laura Maria de Figueiredo Ferreira Guilhoto ; Katia Lin ; Maria Helena da Silva Noffs ; Iv ; a de Souza Silva Tudesco ; Erich
• 关键词：Memory ; Neuropsychology ; Proton magnetic resonance spectroscopy ; Interictal epileptiform discharges ; Temporal lobe epilepsy ; Mesial temporal sclerosis
• 刊名：Epilepsy & Behavior
• 出版年：2009
• 出版时间：November 2009
• 年：2009
• 卷：16
• 期：3
• 页码：447-453
• 全文大小：464 K

文摘

Objective

The aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy (¹H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis.

Methods

We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had ¹H-MRS at 1.5 T.

Results

There was a negative correlation between IQ (P = 0.031) and Rey Auditory Verbal Learning Test results (P = 0.022) and epilepsy duration; between¹H-MRS findings and epilepsy duration (P = 0.027); and between N-acetylaspartate (NAA) levels and IEDs (P = 0.006) in contralateral mesial temporal structures in the left MTS group. ¹H-MRS findings, IEDs, and verbal function were correlated.

Conclusions

These findings suggest that IEDs and NAA/(Cho + Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures.