Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

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• 作者：Rafael Scarpa da Costa Neves ; Iv ; a de Souza Silva Tudesco ; Anaclara Prada Jardim ; Lu¨ªs Ot¨¢vio Sales Ferreira Caboclo ; Carmen Lancellotti ; Ta¨ªssa Ferrari-Marinho ; Ana Paula Hamad ; Murilo Marinho ; Ricardo Silva Centeno ; Esper Abr?o Cavalheiro ; Carla Aless ; ra Scorza ; Elza M¨¢rcia Targas Yacubian
• 关键词：Mesial temporal lobe epilepsy ; Mesial temporal sclerosis ; Dentate gyrus ; Granule cell dispersion ; Memory
• 刊名：Seizure
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：21
• 期：9
• 页码：685-690
• 全文大小：448 K

文摘

Purpose

We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS).

Method

Hippocampal specimens from 54 patients with MTLE (27 patients with right MTLE and 27 with left MTLE) and unilateral MTS, who were separated into GCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients¡¯ neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.

Results

GCD occurred in 28 (51.9 % ) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. The presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.

Conclusion

GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined.