Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats

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• 作者：Erdem Kamil Ozer^a ; ^{drekfarma@hotmail.com} ; Mustafa Tugrul Goktas^b ; Ibrahim Kilinc^c ; Hulagu Bariskaner^a ; Ceyhan Ugurluoglu^d ; Alper Bektas Iskit^e
• 关键词：Celecoxib ; Sepsis ; Survival and multiple organ damage ; Vascular hyporeactivity ; Mesenteric arterial blood flow
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：583-589
• 全文大小：1955 K
• 卷排序：86

文摘

Cyclooxygenase (COX)-2 overexpression plays a principal role in sepsis related multiple organ dysfunction and death. Selective and partial COX-2 inhibition by celecoxib without affecting the physiological basal COX-2 activity has benefical effects in sepsis. Celecoxib reduced mortality, vascular dysfunction, mesenteric hypoperfusion and organ damage in cecal ligation and pucture induced septic rats. Selective and partial blockade of COX-2 is a therapeutic target in sepsis therapy