Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases

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• 作者：Tullio Florio
• 关键词：Somatostatin ; Somatostatin receptors ; Phosphotyrosine phosphatase ; Cell proliferation ; Apoptosis ; MAP kinase ; SHP-1 ; SHP-2 ; DEP-1/PTPη
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2008
• 出版时间：14 May 2008
• 年：2008
• 卷：286
• 期：1-2
• 页码：40-48
• 全文大小：708 K

文摘

Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues. Since their molecular cloning, the role of PTPs is emerging as a major regulator of different cell functions including cell proliferation, differentiation, cell to cell interactions, cell matrix adhesion and cell migration. It was demonstrated that PTPs possess high substrate specificity and their activity is tightly regulated. Importantly, different G protein-coupled receptors transduce their biological activities through PTPs. PTPs were identified as down-stream effectors of SSTRs to transduce antiproliferative signals, and so far, three family members (SHP-1, SHP-2 and DEP-1/PTPη) have been identified as selective SSTR intracellular effectors. Here, the molecular mechanisms leading SSTRs to regulate PTP activity are discussed, focusing on recent data showing a close interplay between PTPs and tyrosine kinases to transduce tumoral cell growth arrest following SST analogs administration.