Effects of short term and long term Extremely Low Frequency Magnetic Field on depressive disorder in mice: Involvement of nitric oxide pathway

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• 作者：Alireza Madjid Ansari^a ; Shahrokh Farzampour^b ; Ali Sadr^c ; Babak Shekarchi^b ; Keivan Majidzadeh-A^a ; ^b ; ^{kmajidzadeh@razi.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ELF ; Magnetic fields ; L-NAME ; Depression
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：146
• 期：Complete
• 页码：52-57
• 全文大小：537 K

文摘

Previous reports on the possible effects of Extremely Low Frequency Magnetic Fields (ELF MF) on mood have been paradoxical in different settings while no study has yet been conducted on animal behavior. In addition, it was shown that ELF MF exposure makes an increase in brain nitric oxide level. Therefore, in the current study, we aimed to assess the possible effect(s) of ELF MF exposure on mice Forced Swimming Test (FST) and evaluate the probable role of the increased level of nitric oxide in the observed behavior.

Main methods

Male adult mice NMRI were recruited to investigate the short term and long term ELF MF exposure (0.5 mT and 50 Hz, single 2 h and 2 weeks 2 h a day). Locomotor behavior was assessed by using open-field test (OFT) followed by FST to evaluate the immobility time. Accordingly, NΩ-nitro-l-arginine methyl ester 30 mg/kg was used to exert anti-depressant like effect.

Key findings

According to the results, short term exposure did not alter the immobility time, whereas long term exposure significantly reduces immobility time (p < 0.01). However, it was revealed that the locomotion did not differ among all experimental groups. Short term exposure reversed the anti-depressant like effect resulting from 30 mg/kg of NΩ-nitro-l-arginine methyl ester (p < 0.01).

Significance

It has been concluded that long term exposure could alter the depressive disorder in mice, whereas short term exposure has no significant effect. Also, reversing the anti-depressant activity of L-NAME indicates a probable increase in the brain nitric oxide.