A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues
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- 作者：Rabia Bilge Ö ; zgü ; l Ö ; zdemira ; Alper Tunga Ö ; zdemirb ; alpertungaozdemir@gmail.com" class="auth_mail" title="E-mail the corresponding author ; alpertungaozdemir@mail.ege.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Fatih Oltuluc ; Kamile Kurtd ; Gü ; rkan Yiğittü ; rkc ; Cengiz Kırmaze
- 关键词：CD44 ; CD133 ; Colorectal cancer ; Nanog ; Oct3/4 ; HLA-E ; HLA-G
- 刊名：Annals of Diagnostic Pathology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：25
- 期：Complete
- 页码：60-63
- 全文大小：915 K
文摘
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The expressions of CD44, Nanog, and Oct3/4, but not CD133, significantly increased in the CRC tumor tissues compared with noncancerous tissues.
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The expressions of HLA-G and HLA-E significantly increased in the CRC tumor tissues compared with noncancerous tissues.
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The concomitant expressions of CD133, CD44, Nanog, and Oct3/4 may indicate the presence of CSC-like cell in the CRC tumor tissues.
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The increased expressions of HLA-G and HLA-E in the CRC tumor tissues may be considered an immune-evasive adaptation of tumor cells.