Effect of oral and transdermal hormone therapy on hyaluronic acid in women with and without a history of intrahepatic cholestasis of pregnancy

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• 作者：Pauliina Tuomikoski ; Kristiina Aittomä ; ki ; Tomi S. Mikkola ; Anne Ropponen ; Olavi Ylikorkala
• 关键词：hormone therapy ; hyaluronic acid ; intrahepatic cholestasis of pregnancy ; liver disease
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：198
• 期：4
• 页码：375.e1-375.e5
• 全文大小：129 K

文摘

Objective

Intrahepatic cholestasis of pregnancy predisposes women to liver disorders years after affected pregnancy. We compared the basal levels and responses of hyaluronic acid, a marker of liver fibrosis, and liver transaminases to postmenopausal hormone therapy in women with (n = 20) and without (n = 20) a history of intrahepatic cholestasis of pregnancy.

Study Design

This was a randomized, double-blind, placebo-controlled, crossover trial.

Results

Basal levels of hyaluronic acid were similar in both groups. Two weeks of oral estradiol 2.0 mg/day led to significant but similar (10.9 % to 15.4 % ) rises in hyaluronic acid in both groups. Increasing the dose of oral estradiol to 4.0 mg/day resulted in normalization of the levels, whereas the addition of medroxyprogesterone acetate led to falls (11.0 % to 10.7 % ) in hyaluronic acid. Transdermal estradiol 50 μg led to a rise (3.2 % ) in hyaluronic acid only in the control group. Other liver markers were normal at baseline and during hormone therapy.

Conclusion

Normal basal levels and/or normal responses of hyaluronic acid and other liver markers to hormone therapy in women with previous intrahepatic cholestasis suggest that this therapy does not predispose these women to liver diseases.