sp0030">This study is a randomized, controlled experimental study. In group 1, rats' left main carotid arteries were clamped. Reperfusion was established by releasing the clamp after 1.5 hours. In group 2, the left main carotid artery was clamped, and 20 mg/kg intraperitoneal NAC was administered after 1 hour. The clamp was released 0.5 hour after NAC administration. In group 3, rats' left carotid arteries were clamped, and 50 mg/kg ethyl pyruvate was administered intraperitoneally after 1 hour. The clamp was released 0.5 hour after ethyl pyruvate administration. All tissue samples were collected 2.5 hours after reperfusion. Brain tissues were compared histopathologically.
sp0035">A higher percentage of degenerative neurons was determined in group 1 compared with groups 2 and 3 (P values: P<sup>asup> = .003 and P<sup>csup> = .003, respectively). A significant difference was also observed between groups 2 and 3 (P<sup>bsup> = .003), with the percentage of degenerative neurons being lower in the NAC group than in the ethyl pyruvate group.
sp0040">The use of NAC and ethyl pyruvate reduces injury resulting from ischemia-reperfusion in an experimental animal model of acute ischemic stroke and subsequent reperfusion.