The effect of transdermal 17-β-estradiol on glucose metabolism of postmenopausal women is evident during the oral but not the intravenous glucose administration

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• 作者：Cagnacci ; Angelo ; Tuveri ; Federica ; Cirillo ; Rocco ; Setteneri ; Anna Maria ; Melis ; Gian Benedetto ; et. al.
• 关键词：17-β ; -Estradiol ; Glucose metabolism ; Menopause
• 刊名：Maturitas
• 出版年：1997
• 出版时间：December 15, 1997
• 年：1997
• 卷：28
• 期：2
• 页码：163-167
• 全文大小：431 K

文摘

Objectives: To evaluate the effect of transdermal 17-β-estradiol (50 bc;g/day) on glucose metabolism of postmenopausal women. Study design: A frequently sampled intravenous glucose tolerance test (FSIGT), to calculate insulin sensitivity (S_I) and peripheral glucose utilization independent of insulin (S_G), and an oral glucose tolerance test (75 g; OGTT), were performed in nine postmenopausal women prior to, and after 2 months of, treatment. Results: Estradiol decreased insulin and increased the C-peptide/insulin ratio both during fasting (P<0.02) and OGTT (insulin levels, P<0.01; C-peptide/insulin ratio, P<0.05), but not FSIGT. Glucose levels, C-peptide levels, S_I and S_G were not affected. Conclusions: In spite of unmodified S_I, the reduction of insulin levels and the increase of the C-peptide/insulin ratio, observed during fasting and OGTT, support a beneficial effect of estradiol on glucose metabolism. This effect probably requires the interplay of estradiol with gastrointestinal factors.