N2 extenuates experimental ischemic stroke through platelet aggregation inhibition
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- 作者：Lijian Yanga ; Xi Chena ; Siqi Wanga ; Yuxiang Feia ; Ding Wanga ; Yunman Lia ; yunmanlicpu@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Guangwei Heb ; Qiang Wub ; Shaoxing Chub ; Weirong Fanga ; weirongfang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：N2 ; 4-(2-(1 ; H-imidazol-1-yl) ethoxy)-3-methoxybenzoic acid ; NS ; 0.9% sodium chloride ; ADP ; adenosine diphosphate ; PLA2 ; phospholipase A2 ; MCAO ; middle cerebral artery occlusion ; MCAO/R ; middle cerebral artery occlusion/reperfusion ; AA ; arachidonic acid ; LTs ; leukotrienes ; TXA2 ; Thromboxane A2 ; U46619 ; 9 ; 11- dieoxy- 11α ; 9α-methanoepoxyprostaglandin F2α ; PRP ; platelet-rich plasma ; PPP ; platelet-poor plasma ; TXB2 ; thromboxane B2 ; 6-keto-PGF1α ; 6-keto-prostaglandin F1α ; TTC ; 2 ; 3 ; 5-triphenyl-te
- 刊名：Thrombosis Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：136
- 期：6
- 页码：1310-1317
- 全文大小：1190 K
文摘
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N2 can improve the motor function, learning and memory ability of MCAO/R rats while reducing the infarct volume.
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The protective effect of N2 on MCAO/R rats may be partly through the regulation of TXA2 and PGI2.
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N2 can inhibit thrombosis and platelet aggregation induced by U46619 and ADP both in vitro and vivo.