Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation
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- 作者：Wen Han1 ; Mary E. Sfondouris1 ; Frank E. Jones ; fjones3@tulane.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：4ICD ; HER4 intracellular domain ; ATCC ; American type culture collection ; EGF ; epidermal growth factor ; EGFP ; enhanced green fluorescent protein ; EGFR ; epidermal growth factor family ; ERα ; estrogen receptor alpha ; FBS ; fetal bovine serum ; HEK ; human embryonic kidney ; HRGα ; heregulin alpha ; HRGα1 ; heregulin beta 1 ; NLS ; nuclear localization signal ; PCR ; polymerase chain reaction ; PI3K ; phosphoinositide 3-kinase ; RIP ; regulated intramembrane cleavage ; RT ; reverse transcription ; RTK ; receptor tyrosi
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：323-327
- 全文大小：671 K
文摘
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HER4/4ICD tyrosine 984 mediates a direct interaction with STAT5A.
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4ICD expression with an intact Y984 is sufficient to induce mammary differentiation.
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Mammary differentiation is abolished by disrupting the 4ICD and STAT5A interaction.
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STAT5 expression is required for 4ICD-induced mammary differentiation.