Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway
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- 作者：Ulrike Strunk ; Daniel Gomez Ramos ; Holly A. Saffran ; James R. Smiley ; jsmiley@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akt ; Src family kinase ; PI3 kinase ; Herpesvirus ; Tegument ; Signaling
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：31-35
- 全文大小：793 K
文摘
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We examined the mechanism of Akt activation by the HSV tegument protein VP11/12.
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Activation requires binding of Src family kinases, PI3 kinase p85, and Grb2.
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Grb2 enhances binding of p85 to VP11/12.