Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial
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- 作者：Andreas Schwingshackla ; aschwingshackl@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dai Kimurab ; Cynthia R. Rovnaghic ; Jordy S. Saraviab ; Stephania A. Cormierb ; Bin Tengd ; Alina N. Westb ; Umberto G. Medurie ; Kanwaljeet J.S. Anandf
- 关键词：ARDS ; Acute Respiratory Distress Syndrome ; GC ; glucocorticoid ; EGF ; epidermal growth factor ; FGF-2 ; fibroblast growth factor-2 ; Flt3L ; fms-like tyrosine kinase 3 ligand ; G-CSF ; granulocyte-colony stimulating factor ; GM-CSF ; granulocyte monocyte-colony stimulating factor ; GRO ; growth related cytokine ; INF-α2 ; interferon-α2 ; IFN-γ ; interferon-γ ; IL-1α ; interleukin1α ; IL-1β ; interleukin-1β ; IL-1ra ; interleukin-1 receptor antagonist ; IL-2 ; interleukin-2 ; IL-3 ; interleukin-3 ; IL-4 ; interleukin-4 ; IL-
- 刊名：Cytokine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：63-71
- 全文大小：593 K
文摘
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Low-dose steroid therapy in PARDS is feasible and may improve ventilation and oxygenation.
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The molecular mechanisms underlying potential changes in these outcomes remained unclear.
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This study examines the effects of IV methylprednisolone on plasma biomarkers of PARDS.
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We simultaneously measured cytokines, cell counts and coagulation parameters in PARDS.
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We report statistical models useful for future RCTs to predict ARDS severity and outcomes.