New Synthetic Route to the Alkaloid Withasomnine by Ring Transformation of a Functionalized Cyclopropanol via the Parent Pyrrolo[1,2-b]pyrazole

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• 作者：Kulinkovich ; Oleg ; Masalov ; Nikolai ; Tyvorskii ; Vladimir ; De Kimpe ; Norbert ; Keppens ; Marian
• 刊名：Tetrahedron Letters
• 出版年：1996
• 出版时间：February 12, 1996
• 年：1996
• 卷：37
• 期：7
• 页码：1095-1096
• 全文大小：102 K

文摘

Withasomnine has been prepared by rearrangement of 1-(3-chloropropyl)-cyclopropanol into 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole, followed by bromination and [NiCl₂(dppp)]-catalyzed phenylation.