A Convenient Synthesis of 3-Functionalized 5-Alkoxymethyl- and 5-Phenoxymethyl-2(5H)-Furanones and Their Transformations into Related Epoxy and Methylene Lactones
详细信息 查看全文
- 作者：Tyvorskii ; Vladimir I. ; Kukharev ; Alexander S. ; Kulinkovich ; Oleg G. ; De Kimpe ; Norbert ; et. al.
- 刊名：Tetrahedron
- 出版年：1998
- 出版时间：February 26, 1998
- 年：1998
- 卷：54
- 期：9
- 页码：1801-1808
- 全文大小：427 K
文摘
A convenient procedure for the preparation of 3-functionalized 5-alkoxymethyl- and 5-phenoxymethyl-2(5H)-furanones is described. The method is based on the condensation of various β-alkoxy- or β-phenoxy-α-hydroxy ketones with β-activated esters in the presence of catalytic amounts of sodium methoxide. Results are reported showing the possible transformations of these 2(5H)-furanones into related epoxy and α-methylene lactones.