Facile synthesis of caerulomycin E by the formation of 2,2′-bipyridine core via a 2-pyridyl substituted 4H-pyran-4-one. Formal synthesis of caerulomycin A

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• 作者：Denis N. Bobrov ; Vladimir I. Tyvorskii
• 关键词：Caerulomycins ; 4H-Pyran-4-ones ; 2 ; 2′ ; -Bipyridines ; Claisen condensation
• 刊名：Tetrahedron
• 出版年：2010
• 出版时间：17 July 2010
• 年：2010
• 卷：66
• 期：29
• 页码：5432-5434
• 全文大小：150 K

文摘

A new approach to caerulomycins A and E via a 6-methyl-2-(2-pyridyl)-4H-pyran-4-one is described. The pyranone precursor is prepared by Claisen condensation of acetylacetone enol ether with ethyl picolinate.