Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives

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• 作者：Yue-Ling Zhao ; Yeh-Long Chen ; Feng-Shuo Chang ; Cherng-Chyi Tzeng
• 关键词：4-Anilino-2-phenylquinoline derivatives ; Cytotoxic activity ; Anticancer agents
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2005
• 出版时间：August 2005
• 年：2005
• 卷：40
• 期：8
• 页码：792-797
• 全文大小：195 K

文摘

The present report describes the synthesis and cell growth inhibition of certain 4-anilino-2-phenylquinoline derivatives. 4-(4-Acetylphenylamino)-6-methoxy-2-phenylquinoline (11), its oxime 15a, and its methyloxime 15b, exhibited significant cytotoxicity against all 60 cancer cells with mean GI₅₀ values of 3.89, 3.02, and 3.89 μM, respectively, while 4-(4-acetylanilino)-6-methoxy-2-phenylquinoline-3-carboxylic acid (9) and its 3-carboxylic acid congeners 13a, 13b, 14a, and 14b were inactive, indicated free carboxylic acid at C(3) position is unfavorable. The steric hindrance exerted by the 3-carboxylate in 9, 13, and 14 may prevent the adjacent phenyl ring to lie coplanar with quinoline, which leads to the devoid of cytotoxicity. The comparable cytotoxicity of oxime 15a, methyloxime 15b, and the ketone precursor 11 implied a hydrogen-bonding accepting group at C(4) position of 4-anilino-moiety is crucial for cytotoxicity. Among these compounds, 11 is especially active against the growth of certain solid cancer cells such as NCI-H226 (non-small cell lung cancer), MDA-MB-231/ATCC (breast cancer), and SF-295 (CNS cancer) with GI₅₀ values of 0.94, 0.04, and < 0.01 μM respectively.