Alveolar Bone Grafting in Association With Polyostotic Fibrous Dysplasia and Bisphosphonate-Induced Abnormal Bone Turnover in a Bilateral Cleft Lip and Palate Patient: A Case Report

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• 作者：Yasumitsu Kodama ; DDS ; PhD^? ; ^{damadama@dent.niigata-u.ac.jp} ; Akira Ogose ; MD ; PhD^&dagger ; ; Yoshimitsu Oguri ; DDS ; PhD^&Dagger ; ; Sobhan Ubaidus ; DDS ; PhD^§ ; ; Tateyuki Iizuka ; MD ; DDS ; PhD^¡Î ; Ritsuo Takagi ; DDS ; PhD^¶ ;
• 刊名：Journal of Oral and Maxillofacial Surgery
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：70
• 期：9
• 页码：e500-e508
• 全文大小：2489 K

文摘

A case is presented of extensive alveolar bone grafting in a patient with bilateral cleft lip and palate and polyostotic fibrous dysplasia. The patient previously underwent bisphosphonate therapy. Because of an abnormal and often decreased bone turnover caused by the fibrous dysplasia and the bisphosphonate therapy, bone grafting in such a patient poses several potential difficulties. In addition, the histomorphometric analysis of the bone grafts showed markedly decreased bone turnover. However, alveolar bone grafting using the iliac crest was performed successfully. Sufficient occlusion was achieved by postoperative low-loading orthodontic treatment.