Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes

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• 作者：Keith W. Dunaway¹ ; ² ; ³ ; ⁴ ; ⁷ ; M. Saharul Islam¹ ; ² ; ³ ; ⁴ ; ⁷ ; Rochelle L. Coulson¹ ; ² ; ³ ; ⁴ ; S. Jesse Lopez¹ ; ² ; ³ ; ⁴ ; Annie Vogel Ciernia¹ ; ² ; ³ ; ⁴ ; Roy G. Chu¹ ; ² ; ³ ; ⁴ ; Dag H. Yasui¹ ; ² ; ³ ; ⁴ ; Isaac N. Pessah⁴ ; ⁵ ; Paul Lott² ; Charles Mordaunt¹ ; ² ; ³ ; ⁴ ; Makiko Meguro-Horike⁶ ; Shin-ichi Horike⁶ ; Ian Korf² ; Janine M. LaSalle¹ ; ² ; ³ ; ⁴ ; ⁸ ; ^{jmlasalle@ucdavis.edu}
• 关键词：autism ; copy number variants ; persistent organic pollutants ; epigenetic ; DNA methylation ; chromatin ; gene x environment interaction
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：3035-3048
• 全文大小：3121 K
• 卷排序：17

文摘

The Dup15q postmortem brain exhibited global DNA hypomethylation over synaptic genes The Dup15q cell model revealed cumulative effects of duplications and PCB 95 exposure Increased UBE3A in Dup15q reduced RING1, affecting transcription of synaptic genes Known druggable autism genes were enriched in cumulative genetic and PCB 95 lists