Nitric oxide interacts with mitochondrial complex III producing antimycin-like effects
详细信息 查看全文
- 作者：Darí ; o E. Iglesias ; diglesias@ffyb.uba.ar" class="auth_mail" title="E-mail the corresponding author ; Silvina S. Bombicino ; Laura B. Valdez ; Alberto Boveris
- 关键词：Nitric oxide ; Cytochrome bc1 complex ; S-nitrosoglutathione (GSNO) ; Spermine-NONOate (SPER-NO) ; Ubiquinone-cytochrome b area ; Superoxide anion ; Hydrogen peroxide ; Electron paramagnetic resonance (EPR) ; Ubisemiquinone
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：602-613
- 全文大小：692 K
文摘
- •
In submitochondrial particles, NO inhibits complex II-III (but not II) activity.
- •
The inhibition leads to an accumulation of reduced cyt. b, independently on [O2].
- •
NO increases ubisemiquinone EPR signal and, in turn, O2•− and H2O2 production rates.
- •
H2O2 production is also enhanced in coupled mitochondria exposed to NO.
- •
These effects are similar to those reported for the classical inhibitor antimycin.