Identification of Pif1 helicases with novel accessory domains in various amoebae
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- 作者：Ashley Harmana ; A.Harman@latrobe.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sam Mannab
- 关键词：G4 ; G-quadruplex ; HGT ; horizontal gene transfer ; CUE ; coupling of ubiquitin conjugation to endoplasmic reticulum degradation ; UBA ; ubiquitin-associated ; Smr ; small MutS-related ; ORC ; origin recognition complex ; UDGase ; uracil DNA glycosylase
- 刊名：Molecular Phylogenetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：64-74
- 全文大小：2461 K
文摘
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We have identified ten amoebal Pif1 helicases possessing novel accessory domains.
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Domains are involved in ubiquitination, DNA replication or nucleic acid binding.
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These proteins evolved via horizontal gene transfer, gene duplication and fusion.
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Acanthamoeba accessory domains were acquired from fungi in two different phyla.
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These domains have likely improved or expanded the roles of amoebal Pif1 helicases.