Mycophenolic acid as a latent agonist of PPARγ
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- 作者：Makoto Ubukata ; Hitomi Takamori ; Misaki Ohashi ; Shinya Mitsuhashi ; Kaoru Yamashita ; Tomohisa Asada ; Noriyuki Nakajima ; Nobuyasu Matsuura ; Mie Tsuruga ; Keiko Taki ; Junji Magae
- 关键词：Mycophenolic acid ; IMPDH ; PPARγ ; 3T3-L1 ; Inhibitor ; SPR
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：1 September 2007
- 年：2007
- 卷：17
- 期：17
- 页码：4767-4770
- 全文大小：167 K
文摘
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor γ (PPARγ).