Neural and genetic correlates of binge drinking among college women

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• 作者：Lance O. Bauer^a ; ^{lbauer@uchc.edu" class="auth_mail} ; ^{bauer@PSYCHIATRY.UCHC.EDU" class="auth_mail} ; Natalie A. Ceballos^b
• 关键词：Alcohol ; Binge drinking ; Gene ; CHRM2 ; Contingent negative variation ; Evoked potential ; Electroencephalography ; College students ; Time
• 刊名：Biological Psychology
• 出版年：March, 2014
• 年：2014
• 卷：97
• 期：Complete
• 页码：43-48
• 全文大小：564 K

文摘

Ninety-seven female students were assigned to groups consisting of 55 infrequent and 42 frequent binge drinkers. The groups were compared on self-report measures of impulsivity, sensation seeking, and alexithymia, as well as several measures relevant to neural and genetic mechanisms, such as brain activation during a time estimation task and selected genotypes. Analyses of stimulus-locked brain activity revealed a slow cortical potential over the right parietal cortex during time estimation that was more negative among frequent binge drinkers. This group also showed a greater prevalence of a CHRM2 genotype previously associated with substance dependence and Major Depressive Disorder as well as a modest elevation on a non-planning impulsiveness scale. We conclude that the enhanced brain activation shown by binge drinkers compensates for an underlying deficit. That deficit may be reflected in poor planning skills and a genetic difference indicating increased risk for problems in later life.