Uterine muscle contractant from the root of Dalbergia saxatilis

详细信息    查看全文

• 作者：Uchendu ; C.N. ; Leek ; B.F.
• 关键词：Dalbergia saxatilis ; Saponins ; Uterine muscle contractant activity
• 刊名：Fitoterapia
• 出版年：1999
• 出版时间：February 1, 1999
• 年：1999
• 卷：70
• 期：1
• 页码：50-53
• 全文大小：130 K

文摘

Contractile responses of uterine muscle strips to a saponin (DSS) isolated from the root of Dalbergia saxatilis was investigated in the rat. Uterine muscle response to the glycoside was characterized by a single but transient contraction that was concentration-dependent, with an ED<sub>50sub> of 0.13 mg/ml and 0.04 mg/ml as the lowest active concentration. Atropine sulphate (0.69 μmol) abolished uterine muscle responses induced by acetylcholine (1.82 μmol) but failed to block responses to submaximal concentration of DSS (0.24 mg/ml), suggesting that responses to DSS were not mediated by cell membrane cholinoceptor activation.