Preliminary studies on the anti-ulcer potentials of Vitex doniana crude extracts on experimental rat model of ethanol induced gastric ulcer

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• 作者：Onwukwe Okechukwu Steven^a ; ^{okechukwu.onwukwe@unn.edu.ng" class="auth_mail" title="E-mail the corresponding author} ; Achukwu Peter Uwadiegwu^a ; Azubike Nkiruka Chinonyelum^a ; Nwachukwu Daniel Chukwu^b ; Onyemelukwe Anulika Obianuju^a ; Uchendu Ikenna Kingsley^a ; Eluke Blessing Chekwube^a
• 关键词：Gastric ulcers ; Anti-ulcer ; Vitex doniana ; Ethnopharmacology
• 刊名：Asian Pacific Journal of Tropical Disease
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：6
• 期：9
• 页码：736-740
• 全文大小：681 K

文摘

To investigate antiulcerogenic potentials of the crude extracts of Vitex doniana against ethanol induced gastric ulcer.

Methods

Twenty four rats divided into 6 groups (I–VI) of 4 animals each were used. The animals were fasted for 24 h at the end of which Group I received a single dose of 10 mL/kg of saline; Group II received a single dose of 100 mg/kg cimetidine intramuscularly; Groups III and IV received single doses of 200 mg/kg and 400 mg/kg body weight of the methanol extract while Groups V and VI received 200 mg/kg and 400 mg/kg body weight of the aqueous extract respectively. After 30 min, each animal received 1 mL/kg body weight of absolute ethanol orally and was sacrificed 1 h later under chloroform anesthesia. The animals' stomachs were excised and the ulcers were counted and scored with the aid of a magnifying lens (×10). The mean ulcer index and ulcer preventive index were calculated for each group.

Results

A statistically significant decrease (P < 0.05) in mean ulcer index was observed in Groups II, IV and V compared to that of control Group I. Calculated percentage ulcer preventive index showed a 97%, 53%, 82%, 82% and 22% percentage preventive index for Groups II, II, IV, IV and VI respectively.

Conclusions

Crude extracts of Vitex doniana possess antiulcer properties against ethanol induced gastric ulcers.