RhoB enhances migration and MMP1 expression of prostate cancer DU145

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• 作者：Misao Yoneda ; Yoshifumi S. Hirokawa ; Atsuyuki Ohashi ; Katsunori Uchida ; Daisuke Kami ; Masatoshi Watanabe ; Toyoharu Yokoi ; Taizo Shiraishi ; Shinya Wakusawa
• 关键词：RhoB ; GSK-3 ; MMP1 ; Prostate cancer
• 刊名：Experimental and Molecular Pathology
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：88
• 期：1
• 页码：90-95
• 全文大小：1366 K

文摘

Rho family protein regulates variety of cellular functions as cytoskeletal organization, cell proliferation and apoptosis. In the present study, we demonstrate that RhoB-overexpressed prostate cancer cells showed an enhanced cell motility and the administration of the GSK-3 inhibitors inhibited this increase in migration. Among the extracellular matrix and adhesion-related molecules, MMP1 RNA expression was increased in RhoB-overexpressed cells, administration of MMP inhibitor suppressed the collagen gel invasion in these cells. This is the first report evaluating RhoB function and the downstream signaling events in prostate cancer cell. Our results indicate that RhoB promotes cell motility and invasion in a metastatic prostate cancer cell.