Comparison of Outcomes of 8/8 and 7/8 Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Cord Blood Transplantation in Adults with Acute Leukemia
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- 作者：Seitaro Terakura1 ; tseit@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshiko Atsuta2 ; 3 ; Nobuhiro Tsukada4 ; Takeshi Kobayashi5 ; Masatsugu Tanaka6 ; Junya Kanda7 ; Yuho Najima5 ; Takahiro Fukuda8 ; Naoyuki Uchida9 ; Satoshi Takahashi10 ; Tokiko Nagamura-Inoue11 ; Yasuo Morishima12 ; Koichi Miyamura13 ; for the Japan Society for Hematopoietic Cell Transplantation
- 关键词：Graft source ; Umbilical cord blood transplantation ; Unrelated volunteer donor ; Bone marrow transplantation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：330-338
- 全文大小：827 K
文摘
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We compared transplantation outcomes of highly allele-matched unrelated bone marrow transplantation and cord blood transplantation.
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A total of 2472 first transplantations for adult acute leukemia were included.
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Comparable survival were observed between 8/8 allele–matched unrelated bone marrow transplantation and cord blood transplantation.
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7/8 Unrelated bone marrow transplantation showed inferior survival to 8/8 unrelated bone marrow transplantation for patients with acute myeloid leukemia.
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Cord blood can be preferred to 7/8 unrelated bone marrow in patients with acute myeloid leukemia.