Investigating Brain Network Characteristics Interrupted by Covert White Matter Injury in Patients with Moyamoya Disease: Insights from Graph Theoretical Analysis
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- 作者：Ken Kazumata1 ; kazumata@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Khin Khin Tha2 ; Hisashi Narita3 ; Hideo Shichinohe1 ; Masaki Ito1 ; Haruto Uchino1 ; Takeo Abumiya1
- 关键词：Brain network ; Connectivity ; Diffusion tensor imaging ; Graph theoretical analysis ; Moyamoya disease
- 刊名：World Neurosurgery
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：654-665.e2
- 全文大小：7884 K
文摘
Chronic ischemia in adult moyamoya disease (MMD) reduces the integrity of normal-appearing white matter (WM). We investigated whether covert WM impairment alters large-scale brain networks and specific neural circuits associated with neurocognitive dysfunction in MMD. Forty-six participants (control, n = 23; MMD, n = 23) were examined using diffusion tensor imaging and streamline tractography. Structural connectivity among 90 cortical and subcortical brain regions was evaluated using the mean fractional anisotropy along the fiber tracts. Graph theoretical analysis was used to measure network parameters and inter-regional connectivity. Global network parameters were reduced in patients with MMD, including cluster coefficient (controls vs. MMD: 3.62 ± 0.24 vs. 3.26 ± 0.36; P < 0.0001), characteristic path length (controls vs. MMD: 1.20 ± 0.02 vs. 1.17 ± 0.01; P < 0.001), and small-world property (controls vs. MMD: 3.07 ± 0.18 vs. 2.83 ± 0.27; P < 0.001). Reduced pairwise connectivity was found in prefrontal neural circuits within the middle/inferior frontal gyrus; supplementary motor area; and insular, inferior temporal, and dorsal cingulate cortices. Covert WM microstructural changes in patients with MMD alter large-scale brain networks, as well as lateral prefrontal neural circuits. Evaluation of structural connectivity may be useful to assess the severity of chronic ischemic injury from a network perspective.