Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance
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- 作者：Mayte Alvarez-Crespo1 ; 2 ; Robert I. Csikasz3 ; Noelia Martí ; nez-Sá ; nchez1 ; 2 ; Carlos Dié ; guez1 ; 2 ; Barbara Cannon3 ; Jan Nedergaard3 ; jan@metabol.su.se" class="auth_mail" title="E-mail the corresponding author ; Miguel Ló ; pez1 ; 2 ; m.lopez@usc.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; Brown adipose tissue ; Hypothalamus ; Thyroid hormones ; UCP1
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：5
- 期：4
- 页码：271-282
- 全文大小：2919 K
文摘
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Central thyroid hormone (TH) increases brown adipose tissue (BAT) thermogenesis.
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Central TH increases oxygen consumption and energy expenditure.
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Central TH increases food intake.
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Central TH promotes britening/beiging of white adipose tissue (WAT).
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All these metabolic effects of central TH are lost in UCP1 knockout mice.