Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

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• 作者：Qingzhang Zhu¹ ; Sarbani Ghoshal¹ ; Richa Tyagi² ; Anutosh Chakraborty¹ ; ^{achakrab@scripps.edu}
• 关键词：IP6K ; Obesity ; Diabetes ; Energy expenditure ; β-oxidation
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：73-85
• 全文大小：2714 K
• 卷排序：6

文摘

Global IP6K1 deletion protects mice from DIO and insulin resistance, irrespective of environmental temperature conditions. Chow diet-fed IP6K1-KO mice expend more energy at 5 °C. High fat diet-fed IP6K1-KO mice oxidize more carbohydrate at 5 °C; whereas they oxidize more fat at 23 °C and 30 °C. Enhanced expression of UCP1, but not other EE markers, is partly impaired in high fat diet-fed IP6K1-KO mice at 30 °C. IP6K1 promotes cellular fat accumulation by diminishing AMPK mediated energy metabolism.