The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition

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• 作者：Jessica Brandi^a ; ¹ ; Daniela Cecconi^a ; ¹ ; Marco Cordani^b ; ¹ ; Margalida Torrens-Mas^c ; ^d ; ^e ; Raffaella Pacchiana^b ; Elisa Dalla Pozza^b ; Giovanna Butera^b ; Marcello Manfredi^f ; ^g ; Emilio Marengo^f ; Jordi Oliver^c ; ^d ; ^e ; Pilar Roca^c ; ^d ; ^e ; Ilaria Dando^b ; ^{ilaria.dando@univr.it} ; Massimo Donadelli^b ; ^{massimo.donadelli@univr.it}
• 关键词：Cancer ; Metabolism ; Uncoupling proteins ; UCP2 ; Warburg effect ; Proteomics
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：305-316
• 全文大小：1305 K
• 卷排序：101

文摘

Proteomic profiling reveals several metabolic proteins/enzymes regulated by UCP2. UCP2 induces hnRNPA2/B1 through its antioxidant function in pancreatic cancer cells. UCP2 stimulates the expression of GLUT1, PKM2 and the secretion of L-lactic acid. UCP2 counteracts pancreatic cancer mitochondrial respiration and OXPHOS. UCP2 sensitizes pancreatic cancer cells to the glycolytic inhibitor 2-deoxy-D-glucose.