Transcription factor gene GATA2: Association of leukemia and nonsynonymous to the synonymous substitution rate across five mammals
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- 作者：Tarikul Huda Mazumder ; Arif Uddin ; Supriyo Chakraborty ; supriyoch_2008@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GATA2 ; Transcription factor ; Amino acid substitution ; Mutation rate
- 刊名：Genomics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：107
- 期：4
- 页码：155-161
- 全文大小：1224 K
文摘
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The codons ending with G/C base was mostly favored over A/T–ending base in the coding sequences of GATA2 across mammals.
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Correlation coefficients between codon usage and GC3s suggested that codon usage of GATA2 has been influenced by GC bias.
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RSCU values of GATA2 gene suggested that the C–ending codons were mostly favored in comparison to G–ending codons.
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Significant difference in nonsynonymous substitution rate indicates a divergent evolution in the mammals for GATA2 gene.
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Mutation pressure played a minor role while natural selection played a major role in the codon usage patterns of GATA2 gene.