The absence of pleiotrophin modulates gene expression in the hippocampus in vivo and in cerebellar granule cells in vitro
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- 作者：Celia Gonzá ; lez-Castilloa ; 1 ; Daniel Ortuñ ; o-Sahagú ; nb ; 1 ; dortuno@cucs.udg.mx" class="auth_mail" title="E-mail the corresponding author ; Carolina Guzmá ; n-Brambilac ; Ana Laura Má ; rquez-Aguirred ; Rita Raisman-Vozarie ; Mercé ; Pallá ; sf ; Argelia E. Rojas-Mayorquí ; ng ; argelia.rojas@academicos.udg.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pleiotrophin ; Neuromodulation ; Hippocampus ; Cerebellar granule cells ; Gene expression ; Caspase 6 ; AKT
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：113-121
- 全文大小：967 K
文摘
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Expression of genes for neuroprotection, cell differentiation / proliferation is modified in the hippocampus of PTN-/- mice.
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PTN silencing in NPCs in vitro induces an increase in synaptophysin expression.
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The silencing of PTN upregulates the expression of Caspase 6, Ers 1, Mgst3 and 18s RNA, in vivo and in vitro.
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Signaling in the absence of PTN is mediated by a decrease in AKT phosphorylation and a decrease in expression of c-Jun.