Toxicokinetics of pyrethroid metabolites in male and female rats

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• 作者：Jun Ueyama ; Naoko Hirosawa ; Aiko Mochizuki ; Akiko Kimata ; Michihiro Kamijima ; Takaaki Kondo ; Kenji Takagi ; Shinya Wakusawa ; Takaaki Hasegawa
• 关键词：Pyrethroid metabolites ; Tissue distribution ; Toxicokinetics
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：30
• 期：1
• 页码：88-91
• 全文大小：260 K

文摘

The toxicokinetic characteristics of 3-phenoxybenzyl alcohol (3PBAlc) and 3-phenoxybenzaldehyde (3PBAld; metabolites of pyrethroid [PYR] after 25 mg/kg, single intravenous administration), were investigated in male and female rats. The systemic clearance (Cl) of 3PBAlc in females (0.403 ± 0.040 l/h/kg) was significantly larger than that of males (0.227 ± 0.036 l/h/kg). The plasma concentration-time curve of 3PBAld decreased gradually and then increased again 1 and 2 h after injection, suggesting the effect of enterohepatic circulation. The present study characterized the elimination and distribution of PYR metabolites and suggests that gender-related difference exists in the toxicokinetics of 3PBAlc and 3PBAld in rats.