Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase
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- 作者：Lucie Aumailleya ; Marie Julie Duboisb ; Chantal Garanda ; André ; Maretteb ; Michel Lebela ; michel.lebel@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vitamin C ; Metabolomic ; Transcriptome ; Werner syndrome ; Mouse aging ; Endoplasmic reticulum
- 刊名：Experimental Gerontology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：192-203
- 全文大小：1242 K
文摘
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Wrn mutant mice show altered metabolic profile before exhibiting age tissue changes.
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Young Wrn mutant mice show abnormal increase of cardiovascular risk factors.
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Liver transcriptomic profiles coincide with the metabolic anomalies in Wrn mutant mice.
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A mislocalized WRN mutant protein increases oxidative stress in endoplasmic reticulum.
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Vitamin C treatment rescues the abnormal metabolic profile of Wrn mutant mice.