Collagencin, an antibacterial (G+ & G-) peptide identified from fish collagen hydrolysate.
The peptide completely inhibited the growth of S. aureus at 1.88 mM and non-toxic at 470 μM.
The secondary structure was mainly composed by β-sheet and turn as determined by CD and MD.
Collagencin interacts with both anionic and zwitterionic lipids as shown with CD and MD.
Collagencin antibacterial action probably follows a carpet mechanism.