Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane
详细信息 查看全文
- 作者：Nadia Ennaasa ; Riadh Hammamia ; riadh.hammami@fsaa.ulaval.ca" class="auth_mail" title="E-mail the corresponding author ; Ahmed Gomaaa ; Franç ; ois Bé ; dardb ; É ; ric Bironb ; Muriel Subiradea ; Lucie Beaulieua ; c ; lucie.beaulieu@fsaa.ulaval.ca" class="auth_mail" title="E-mail the corresponding author ; Ismail Flissa ; ismail.fliss@fsaa.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fish collagen ; Collagencin ; Antibacterial activity ; Mechanism of action ; Circular dichroism ; Molecular dynamics
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：642-647
- 全文大小：1727 K
文摘
- •
Collagencin, an antibacterial (G+ & G-) peptide identified from fish collagen hydrolysate.
- •
The peptide completely inhibited the growth of S. aureus at 1.88 mM and non-toxic at 470 μM.
- •
The secondary structure was mainly composed by β-sheet and turn as determined by CD and MD.
- •
Collagencin interacts with both anionic and zwitterionic lipids as shown with CD and MD.
- •
Collagencin antibacterial action probably follows a carpet mechanism.