Synthesis of unsaturated lactone moieties by asymmetric hetero Diels–Alder reactions with binaphthol-titanium complexes

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• 作者：Quitschalle ; Monika ; Christmann ; Mathias ; Bhatt ; Ulhas ; Kalesse ; Markus
• 刊名：Tetrahedron Letters
• 出版年：2001
• 出版时间：February 12, 2001
• 年：2001
• 卷：42
• 期：7
• 页码：1263-1265
• 全文大小：64.6 K

文摘

Natural products like ratjadone and callystatin A contain an α,β-unsaturated lactone moiety which adds to the biological activity of these compounds. Here we report a rapid and practical access to lactone precursor 3 by an asymmetric hetero Diels–Alder reaction as the key step and its subsequent transformation into a suitable building block 4.