Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Focus on Longitudinal Assessment of Donor Chimerism, Extramedullary Disease, and High-Risk Cytogenetic Features
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- 作者：Leo Rasche1 ; LRasche@uams.edu" class="auth_mail" title="E-mail the corresponding author ; Christoph Rö ; llig2 ; Gernot Stuhler3 ; Sophia Danhof1 ; Stephan Mielke1 ; Goetz Ulrich Grigoleit1 ; Lea Dissen1 ; Lea Schemmel1 ; Jan Moritz Middeke2 ; Viktoria Rü ; cker4 ; Martin Schreder1 ; Johannes Schetelig2 ; Martin Bornhä ; user2 ; Hermann Einsele1 ; Christian Thiede2 ; Stefan Knop1
- 关键词：Allogeneic hematopoietic cell transplantation ; Multiple myeloma ; Chimerism ; Extramedullary disease ; Donor lymphocyte infusion ; High-risk cytogenetics
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：22
- 期：11
- 页码：1988-1996
- 全文大小：1793 K
文摘
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This is a study of serial donor chimerism analysis (>2300 samples) in 155 recipients of allografts for multiple myeloma.
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A chimerism drop without relapse was rare.
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The predictive value of serial chimerism analysis for heralding relapse was limited because of the high frequency of extramedullary relapses after allo-SCT.
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In multivariable analysis, the most relevant variable for OS was progressive disease before allo-SCT.
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Adverse cytogenetics such as del17p, t(4,14) or amp(1q21) were not associated with shorter survival after allo-SCT in our series.