Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment
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- 作者：Thomas Blank1 ; Claudia N. Detje2 ; Alena Spieß ; 1 ; Nora Hagemeyer1 ; Stefanie M. Brendecke1 ; Jakob Wolfart3 ; Ori Staszewski1 ; Tanja Zö ; ller1 ; Ismini Papageorgiou4 ; Justus Schneider4 ; Ricardo Paricio-Montesinos1 ; Ulrich L.M. Eisel5 ; Denise Manahan-Vaughan6 ; Stephan Jansen6 ; Stefan Lienenklaus2 ; 7 ; Bao Lu8 ; Yumiko Imai9 ; Marcus Mü ; ller10 ; Susan E. Goelz11 ; Darren P. Baker12 ; Markus Schwaninger13 ; Oliver Kann4 ; Mathias Heikenwalder14 ; 15 ; Ulrich Kalinke2 ; Marco Prinz1 ; 16 ; marco.prinz@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：behavior ; depression ; type I interferon ; MAVS ; IPS-1 ; IFN ; IFNAR1 ; virus infection ; influenza ; signal transduction ; brain ; endothelia ; epithelia ; neurons ; CXCL10 ; CXCR3
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 April 2016
- 年：2016
- 卷：44
- 期：4
- 页码：901-912
- 全文大小：4594 K
文摘
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Viruses induce depressive behavior and ISG15 expression at the blood-brain barrier
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IFNAR1 expression on neural cells is not involved in IFN-β-induced sickness behavior
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IFNAR1 expression on brain endothelial and epithelial cells drives behavioral changes
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Brain endothelia- and epithelia-derived CXCL10 inhibits hippocampal synaptic plasticity