Added value of MRI for the prenatal diagnosis of isolated orofacial clefts and comparison with ultrasound

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• 作者：A. Dabadie^a ; ^{alexia.dabadie@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; E. Quarello^b ; ^c ; N. Degardin^d ; R. Desbriere^c ; H. Heckenroth^e ; S. Sigaudy^e ; G. Gorincour^a ; ^e
• 关键词：Prenatal diagnosis ; Cleft lip/palate ; Magnetic resonance imaging ; Prenatal ultrasonography ; Fetus
• 刊名：Diagnostic and Interventional Imaging
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：97
• 期：9
• 页码：915-921
• 全文大小：1713 K

文摘

To evaluate the added value of fetal magnetic resonance imaging (MRI) in diagnosing and assessing isolated orofacial clefts and compare MRI with second-line diagnostic ultrasound.

Materials and methods

In a two-year prospective bicenter study, fetuses with isolated orofacial clefts were reassessed using second-line diagnostic ultrasound and MRI. The results of second line ultrasound and those MRI were compared to each other. The gestational age at the time of ultrasound and MRI, and the final diagnosis for each of the imaging modalities were recorded. Finally, the results of second line ultrasound and those of MRI were compared to the results of neonatal clinical examination after delivery that served as standard of reference.

Results

Twenty-two women were included after informed consent was obtained. On average, diagnostic ultrasound was performed at 25.5 weeks of gestation (range: 24–34 weeks) and MRI at 29.5 weeks of gestation (range: 27–34 weeks). The results of ultrasound and those of MRI findings were strictly consistent in 20 women (20/22; 91%) but differed in 2 women (2/22; 9%). For all fetuses, the final radiological diagnosis was confirmed by clinical examination after delivery.

Conclusion

If ultrasound examination proves technically challenging, fetal MRI can be used to obtain the same diagnostic information in 91% of cases and can help surgeons and interdisciplinary teams provide appropriate antenatal counseling.