Synergistic thermoradiotherapy based on PEGylated Cu₃BiS₃ ternary semiconductor nanorods with strong absorption in the second near-infrared window

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• 作者：Ang Li^a ; Xiang Li^b ; Xujiang Yu^a ; Wei Li^a ; Ruyi Zhao^b ; Xiao An^b ; ^{54andromeda@163.com" class="auth_mail" title="E-mail the corresponding author} ; Daxiang Cui^c ; Xiaoyuan Chen^d ; Wanwan Li^a ; ^{wwli@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Copper bismuth sulfide ; Nanorods ; The second near-infrared (NIR-II) window ; Multimodel imaging ; Thermoradiotherapy
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：Complete
• 页码：164-175
• 全文大小：3689 K

文摘

In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated Cu₃BiS₃ NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu₃BiS₃ NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy.