The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish

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• 作者：Bridgette E. Drummond¹ ; Yue Li¹ ; Amanda N. Marra ; Christina N. Cheng ; Rebecca A. Wingert ; ^{rwingert@nd.edu}
• 关键词：cRNA ; capped RNA ; CS ; corpuscle of Stannius ; DAPT ; N-[N-(3 ; 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester ; DEAB ; 4-diethylaminobenzaldehyde ; DE ; distal early ; DL ; distal late ; fbyc144 ; from beyond ; hpf ; hours post fertilization ; IM ; intermediate mesoderm ; NICD ; Tg(hsp70 ; Gal4 ; UAS ; NICD ; MO ; morpholino ; N ; neck ; P ; podocytes ; PCT ; proximal convoluted tubule ; PD ; pronephric duct ; PST ; proximal straight tubule ; PD ; pronephric duct ; RA ; retinoic acid ; sim1a ; single-minded family bHLH
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：421
• 期：1
• 页码：52-66
• 全文大小：1822 K
• 卷排序：421

文摘

Zebrafish intermediate mesoderm (IM) progenitors express tbx2a and tbx2b. tbx2a or tbx2b deficiency leads to a reduced DL in the pronephros and expanded CS glands. Retinoic acid signaling negatively regulates tbx2a/b during IM development. Notch signaling acts upstream of tbx2a/b to inhibit CS fate.