Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation

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• 作者：Umut Di&#x15f ; el ; Serdar Ö ; ztuzcu ; Ali Ayberk Be&#x15f ; en ; Cemile Karadeniz ; Fatih Kö ; se ; Ahmet Taner Sü ; mbü ; l ; Ahmet Sezer ; Gü ; l Nihal Nursal ; Hü ; seyin Abalı ; Ö ; zg&#
• 关键词：Thymic carcinoma ; Sorafenib ; C-KIT mutation ; C-KIT ; TKI inhibitors
• 刊名：Lung Cancer
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：71
• 期：1
• 页码：109-112
• 全文大小：632 K

文摘

Advanced thymic carcinoma (TC) is a very aggressive disease. To date there are no established treatment options for the refractory and recurrent disease and only a few prospective trials have been conducted in patients with TC. Here we present a case of a relapsed TC patient, who, by using combination chemotherapy, showed a positive response to sorafenib with C-KIT exon 11 mutation.