A Choreography of Nicotinic Receptors Directs the Dopamine Neuron Routine

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• 作者：Mark A. Ungless and Stephanie J. Cragg
• 刊名：Neuron
• 出版年：2006
• 出版时间：15 June 2006
• 年：2006
• 卷：50
• 期：6
• 页码：815-816
• 全文大小：48 K

文摘

Modulation of the mesocorticolimbic dopamine system by nicotinic acetylcholine receptors (nAChRs) is thought to play an important role in both health and addiction. However, a clear understanding of how these receptors regulate in vivo firing activity has been elusive. In this issue of Neuron, Mameli-Engvall and colleagues report an impressive and thought-provoking series of in vivo experiments combining single-unit recordings from dopamine neurons with nAChR subunit deletions and region-specific lentiviral subunit re-expression.