Raman spectroscopy for the analytical quality control of low-dose break-scored tablets
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- 作者：Diego A. Gó ; mez ; Jordi Coello ; Santiago Maspoch ; santiago.maspoch@uab.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acenocoumarol ; Multivariate calibration ; Low dose-pharmaceuticals ; Raman ; Scored tablets
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：30 May 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：207-215
- 全文大小：680 K
文摘
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Raman spectroscopy is proposed for quality analytical control of break-scored tablets.
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The non-destructive analysis of API in whole tablets and potential fragments is possible.
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It allows assessing both the content uniformity and uniformity of distribution of API.
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API mass proportion as low as 0.7% can be determined with an adequate precision.