High-throughput prediction of tablet weight and trimethoprim content of compound sulfamethoxazole tablets for controlling the uniformity of dosage units by NIR
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- 作者：Yanhong Dong ; Juan Li ; Xiaoxiao Zhong ; Liya Cao ; Yang Luo ; Qi Fan ; fanqi787@cqmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Uniformity of dosage units ; Compound sulfamethoxazole tablets ; Tablet weight ; Trimethoprim content ; Near infrared spectroscopy ; Partial least squares regression
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：78-82
- 全文大小：626 K
文摘
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A high-throughput and rapid NIR-PLS method was developed and evaluated.
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The tablet weight of compound sulfamethoxazole tablets was determined.
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The trimethoprim content of compound sulfamethoxazole tablets was determined.
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The work expands NIR applications in controlling the uniformity of dosage units.
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The strategy can be used in the on-line analysis of pharmaceutical tablets.