Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses
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- 作者：Alison Taylor1 ; James A. Harker2 ; Kittiphat Chanthong1 ; Philip G. Stevenson3 ; 4 ; Elina I. Zuniga2 ; Christopher E. Rudd1 ; cer51@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：274-286
- 全文大小：3811 K
文摘
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GSK-3 is a key upstream kinase that contributes to inhibition of PD-1 transcription
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GSK-3 siRNAs or inhibitors block PD-1 transcription to thereby enhance CTL function
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GSK-3 inhibition enhances Tbx21 transcription, which represses PD-1 transcription
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Use of GSK-3 inhibitors in vivo downregulates PD-1 and enhances viral clearance