The most commonly affected region of acquired uniparental disomy in hematologic malignancies is on 9p.

The 9p acquired uniparental disomy can precede JAK2^V617F, though the pathogenic consequences remain unclear.

Both the size and fraction of acquired uniparental disomy can change during disease progression.

The 9p acquired uniparental disomy may contribute to the tumor phenotype beyond its impact on JAK2.